Eluent Strength Translator
The following calculator helps you to predict a solvent system composition that would give similar eluotropic strength for neutral compounds on silica gels.
Guide
Currently, there are 22 solvents, sorted in increasing order of eluent strength on neutral silica gel. The eluent strengths are currently extracted from Louisiana State University Macro server at The Polymer Analysis Laboratory (PAL) Summary of Key Physical data for Baker Analyzed HPLC Solvents page.
Please choose your current and desired solvent systems below.
Current solvent system:
Desired solvent system:
About
While doing TLC (Thin Layer Chromatography) and column chromatography, it might be beneficial to determine other solvent compositions that give similar eluent strength.
The process of determining solvent strength is detailed in this article by Biotage and implemented in this page for easy usage.
👏 Kudos
- Biotage's article on determining solvent strength in flash column chromatography.
- Nick Chiappini's Effective TLC Solvent Strength Translator table and original tweet for the inspiration.
- Stefanfrede's 11st-starter-kit template
📚 More references
- A convenient guide to help select replacement solvents for dichloromethane in chromatography Green Chem., 2012, 14, 3020-3025
- Advanced HPLC method development (see page 8-15)
- Louisiana State University Macro server at The Polymer Analysis Laboratory (PAL) Solvent's page, specifically:
- Professor Murov's table of solvents used in organic chemistry